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We've seen issues with McAfee, even though the e-mail scanning component in the Virusscan Console is noted as "Disabled." Make sure that the McAfee Integration with Notes is truly disabled. If it's running, you will typically see a section under the Actions menu in Notes with entries regarding "Scan this database," etc.
Make sure the following notes.ini parameters are removed:
AddInMenus=NCMenu
EXTMGR_ADDINS=NCExtMgr
There may be relevant items in those parameters, such as Adobe Acrobat, but you don't want any "NC" items.
Even if the entries were initially removed, they tend to slip back in when you apply McAfee patches.
Here's a technote regarding the McAfee parameters: